| ncRNA name | p22phox-siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Mus musculus |
| Tissues/Cell_line | retinas and RPE/choroids |
| Methods | Western blot, immunofluorescent localization, in situ hybridization, siRNA injection, ELISA |
| Expression pattern | associated |
| Functional description | A small-interfering RNA (siRNA) designed against p22phox efficiently reduced the expression of the protein in the eye when delivered by means of recombinant adeno-associated virus (AAV) vector. Vector treatment inhibited CNV in the mouse when delivered into the subretinal space where RPE cells were transduced. |
| PubMed ID | 18665154 |
| Year | 2008 |
| Title | Downregulation of p22phox in retinal pigment epithelial cells inhibits choroidal neovascularization in mice. |
| Drug-related ncRNA | NO |
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